The MiniVent Model 845 Ventilator is a quiet, compact and light weight ventilator. While it was designed specifically for mice, the MiniVent can be used for any animal (e.g. birds and perinatal rats) which requires tidal volumes in the range of 30 to 350 µl and respiratory rates of 60 to 400 breaths per minute.
The MiniVent Model 845 Ventilator is a quiet, compact and light weight ventilator designed specifically for mice. It can be used for any animal (e.g. birds and perinatal rats) which requires tidal volumes in the range of 30 to 350 µl and respiratory rates of 60 to 400 breaths per minute.
The MiniVent Ventilator is a constant-volume respiration pump operating on the Starling principle. Unlike conventional units for larger animals, this ventilator employs a rotary plunger and has no valves. During each ventilation cycle, the plunger performs a synchronized forward and rotating movement. Cleverly arranged bores and channels in the cylinder and plunger control inspiration and expiration during each stroke of the plunger.
The extremely light weight and compact construction, in addition to the convenient rod clamp, allow the MiniVent ventilator to be positioned directly next to the animal. Typical setups with larger ventilators produce large tubing and instrument dead space volumes. These larger volumes introduce greater system compliance which can affect the accuracy with which the full tidal volume is introduced into the animal’s lungs. With the MiniVent, the tidal volume error due to system compliance is reduced to ±3 µl.
Tidal volume and respiration rate can be set exactly to the values required for mouse ventilation. The level of precision and control available to the investigator minimizes the danger of hyperventilation or hypoventilation.
The tidal volume can be varied continuously from 30 to 350 µl during operation without having to interrupt ventilation. The respiration rate is also continuously adjustable from 60 to 400 strokes/min. The expired air can be recovered at the collection port for sampling, recycling or for the generation of a positive end-expiratory pressure (PEEP). Room air or any non-explosive gas mixture can be used to feed the pump intake.
The MiniVent is supplied with 1 x AC Wall Mounted Power Supply (115 V or 220 V); 2 x Silicone Tubing (1.5mm ID, 3.0mm OD, 14cm long); 1 x 1.3mm OD Tracheotomy Cannula (73-2730); 1 x 1.2mm OD Intubation Cannula (73-2844).
A multi-gas inlet adapter is available for the MiniVent so that alternate gas mixtures and nebulized substances are delivered to the MiniVent inlet port at atmospheric pressure. The adapter provides ports for multiple selectable gas mixtures (hypoxic, anesthetic...) and a port for the Aerosol Nebulizer.
|AC Adapter Weight English||0.7||0.7|
|AC Adapter Weight Metric||0.3||0.3|
|Gas Supply||Room air or non-flammable mixed gas||Room air or non-flammable mixed gas|
|Net Weight English||2.2||2.2|
|Net Weight Metric||1||1|
|Number of Animals||1||1|
|PEEP||Provided via attachment of water column||Provided via attachment of water column|
|Respiration Rate Maximum||400||400|
|Respiration Rate Minimum||60||60|
|Respiratory Rate Note||Continuously adjustable from 60 to 400 breaths/min||Continuously adjustable from 60 to 400 breaths/min|
|Sigh Pressure||Not available||Not available|
|Species||Mice, Prenatal Rats, Small Birds||Mice, Prenatal Rats, Small Birds|
|Stroke Volume Note||Continuously adjustable from 0.03 to 0.35 ml/stroke||Continuously adjustable from 0.03 to 0.35 ml/stroke|
|Tital Volume Maximum||0.13 ml/stroke||0.35|
|Tital Volume Minimum||0.03||0.03|
|Voltage Range||110 VAC||230 VAC|
|Weight Range Maximum||50||50|
|Weight Range Minimum||1||1|
|AC Adapter Weight English||0.7 lb||0.7 lb|
|AC Adapter Weight Metric||0.3 kg||0.3 kg|
|Depth English||7.9 in||7.9 in|
|Depth Metric||20 cm||20 cm|
|Height English||3.1 in||3.1 in|
|Height Metric||8 cm||8 cm|
|I E Ratio||1:1||1:1|
|I E Ratio UOM||%||%|
|Net Weight English||2.2 lb||2.2 lb|
|Net Weight Metric||1 kg||1 kg|
|Respiration Rate Maximum||400 breaths/min||400 breaths/min|
|Respiration Rate Minimum||60 breaths/min||60 breaths/min|
|Tidal Volume Maximum||0.13 ml/stroke||0.13 ml/stroke|
|Tidal Volume Minimum||0.03 ml/stroke||0.03 ml/stroke|
|Weight Range Maximum||50 g||50 g|
|Weight Range Minimum||1 g||1 g|
|Width English||3.9 in||3.9 in|
|Width Metric||10 cm||10 cm|
|Optimization of isolated perfused/ventilated mouse lung to study hypoxic pulmonary vasoconstriction||Hae Young Yoo,1 Amy Zeifman,1 Eun A. Ko,1 Kimberly A. Smith,1 Jiwang Chen,1 Roberto F. Machado,1,2 You-Yang Zhao,3 Richard D. Minshall,3,5,6 and Jason X.-J. Yuan1,4||Hypoxic pulmonary vasoconstriction (HPV) is a compensatory physiological mechanism in the lung that optimizes the matching of ventilation to perfusion and thereby maximizes gas exc|
|Activation of calpains mediates early lung neutrophilic inflammation in ventilator-induced lung injury||Dejie Liu , Zhibo Yan , Richard D. Minshall , David E. Schwartz , Yuguo Chen , Guochang Hu||Lung inflammatory responses in the absence of infection are considered to be one of primary mechanisms of ventilator-induced lung injury. Here, we determined the role of calpain in|
|Effect of permanent middle cerebral artery occlusion on Cytoglobin expression in the mouse brain||Zindy Raidaa, , , Riin Reimetsb, c, Anders Hay-Schmidta, Christian Ansgar Hundahla,||Cytoglobin, a new member of the mammalian heme-globin family has been shown to bind oxygen and to have cell protective properties in vitro. Cytoglobin is specifically expressed in|
|Negative Hemodynamic Effects of Pantoprazole at High Infusion Rates in Mice||Bernhard Unsöld1,2,*, Nils Teucher3, Michael Didié1,4, Samuel Sossalla1, Claudius Jacobshagen1, Tim Seidler1, Wolfgang Schillinger1 andGerd Hasenfuß1||Summary Background Pantoprazole has been shown to exert a negative inotropic effect in isolated myocardium. The purpose of this study was to evaluate the hemodynamic effects of pan|
|Protocol for the Induction of Subarachnoid Hemorrhage in Mice by Perforation of the Circle of Willis with an Endovascular Filament||Dominik Bühler, Kathrin Schüller, Nikolaus Plesnila||Genetically engineered mice are a valuable tool to investigate the molecular and cellular mechanisms leading to brain damage following subarachnoid hemorrhage (SAH). Therefore, sev|
|Rapid Onset of Specific Diaphragm Weakness in a Healthy Murine Model of Ventilator-induced Diaphragmatic Dysfunction||Segolene Mrozek, M.D., M.Sc.,* Boris Jung, M.D., Ph.D.,† Basil J. Petrof, M.D.,‡ Marion Pauly, M.Sc.,§ Stephanie Roberge, M.Sc.,§ Alain Lacampagne, Ph.D., Ce´ cile Cassan, Ph.D.,# Jerome Thireau, Ph.D.,** Nicolas Molinari, Ph.D.,†† Emmanuel Futier, M.D., M.Sc.,‡‡ Valerie Scheuermann, M.S.,§§ Jean Michel Constantin, M.D., Ph.D., Stefan Matecki, M.D., Ph.D.,## Samir Jaber, M.D., Ph.D.***||Background: Controlled mechanical ventilation is associated with ventilator-induced diaphragmatic dysfunction, which impedes weaning from mechanical ventilation. To design future c|
|Brain function in iNOS knock out or iNOS inhibited (l-NIL) mice under endotoxic shock||Hanna Schweighöfer1 , Christoph Rummel2 , Konstantin Mayer3 and Bernhard Rosengarten1*||Background: Microcirculatory dysfunction due to excessive nitric oxide productionby the inducible nitric oxide synthase (iNOS) is often seen as a motor of sepsis-related organ dysf|