LS-PVL

iWorx Pressure Volume Loop Software Module is a plug-in software module

for iWorx data acquisition systems that performs pressure volume loop

analysis for hemodynamic research in animals. The software module

provides a powerful and easy to use tool for investigators to measure

and analyze the hemodynamic parameters of cardiac and pulmonary pressure

and volume data acquired by an iWorx recorder.

Cardiac cycle parameters that can be monitored online are:

• Heart Rate,
• End Systolic Pressure,
• End Diastolic Pressure,
• Max Pressure,
• Min Pressure,
• Max dP/dt,
• Min dP/dt,
• Max Volume,
• Min Volume,
• End Systolic Volume,
• End Diastolic Volume,
• Stroke Volume,
• Cardiac Output,
• Ejection Fraction,
• Stroke Work

Further analysis can be performed offline, such as selecting cycles,

calculating Pressure-Volume Area, Potential Energy, Cardiac Efficiency,

and plotting PV Loops, PRSW, Max dp vs EDV, PVA vs EDV, PVA vs ESP, can

be performed. The data and graphs can be copied or exported to the

built-in Journal or any external program.

The software module is plug and play compatible with all iWorx Data Acquisition and Analysis Modules.

Notable Features:

• Real-time XY plotting
• Real-time analysis of PV derived parameters
• Real-time or offline calculation of admittance derived volume using raw signals from the Scisense ADVantage system
• Calibration of classical conductance catheter volume using cuvette method or Baan’s equation
• Volume calculations from sonomicrometry, echo ultrasound or pressure-volume systems
• Calculation of stress-volume loops from VisualSonics echo ultrasound data

PV Loop Calculations:

• Maximum and Minimum Volume
• Diastolic and Systolic Volume
• Stroke Volume
• Cardiac Output
• Ejection Fraction
• End-Systolic Pressure Volume Relationship (ESPVR)
• End-Diastolic Pressure Volume Relationship (EDPVR)
• Preload-Recruitable Stroke Work (PRSW)
• Pressure-Volume Area (PVA)
• Arterial Elastance
• Time-Varying Elastance
• Maximum Power
• Preload-Adjusted Maximal Power
• Potential Energy
• Cardiac Efficiency
• Heart Rate Variability (HRV) Calculations

Plotting:

• PV Loops
• PRSW
• Max dp/dt vs EDV
• PVA vs EDV
• PVA vs ESP
• Time Varying Elastance
• E(t) vs. time
• Averaged PV loops

Detailed information about using the modules is in the LabScribe Manual.